Antipyretic and Analgesic Effects and Precautions of Acetaminophen

Hello, everyone! We are BLEZ Pharmacy in Asakusa.

Today, I would like to talk a little about antipyretics and analgesics.

Acetaminophen, a Commonly Known Antipyretic and Analgesic

Acetaminophen is generally known as an antipyretic and analgesic drug. Various products are available over the counter in Japan, making it easily accessible. Let’s take a closer look at its effects and precautions.

Acetaminophen has the effect of relieving fever and pain. It is commonly used to relieve various types of pain and fever symptoms such as headaches, toothaches, muscle aches, and joint pain. It also helps reduce symptoms of colds and flu. It is widely used because it has a relatively fast onset of action and is generally considered safe.

However, there are several precautions to consider when using acetaminophen products. First, it is important to follow the dosage and frequency of use. Overdosing can potentially damage the liver, so always follow the recommended usage instructions. Additionally, caution is needed when using it with other medications. In particular, avoid combining it with alcohol or other antipyretic and analgesic drugs, as this may increase the burden on the liver.

Furthermore, acetaminophen has side effects. Although rare, allergic reactions, digestive symptoms, and skin symptoms have been reported. If these symptoms occur, discontinue use immediately and consult a doctor.

Also, acetaminophen may not be suitable for certain individuals. If you are pregnant or breastfeeding, or if you have liver or kidney disease, consult your doctor or pharmacist before using it.

When using acetaminophen products, it is important to read the product label and package insert carefully and follow the instructions. If you have any questions or concerns, it is recommended to consult your doctor or pharmacist.

Acetaminophen is an effective drug for relieving common pain and fever symptoms, but it is important to use it correctly and understand the precautions.

Comparison with Loxonin and Ibuprofen

Now, acetaminophen is commonly used as an antipyretic and analgesic, but how does it compare to Loxonin and Ibuprofen, which have similar effects?

First, the difference between acetaminophen and drugs classified as NSAIDs such as Loxonin (loxoprofen) and Ibuprofen (ibuprofen) lies in their mechanism of action. Acetaminophen acts on the central nervous system to suppress pain and fever, but it has little effect on inflammation. On the other hand, NSAIDs have anti-inflammatory effects.

Generally, NSAIDs are said to be more effective than acetaminophen, but within the medical range, it is said that there is no significant difference in the analgesic effect between high-dose acetaminophen and NSAIDs.

Acetaminophen is suitable for relieving pain and fever symptoms, but NSAIDs may be more effective when inflammation is involved. However, NSAIDs have the risk of gastrointestinal and renal disorders, so caution is especially needed when using them for long periods or in the elderly.

Furthermore, NSAIDs have the effect of inhibiting blood clotting, which may increase the risk of bleeding. In contrast, acetaminophen does not affect blood clotting, so it is an option for patients with bleeding disorders or those who are susceptible to blood clotting after surgery.

However, acetaminophen carries the risk of liver damage due to excessive intake, so it is important to pay close attention to the dosage and frequency of use. Like NSAIDs, it is important to follow the doctor’s instructions when using acetaminophen for long periods or in combination with other drugs.

Acetaminophen and NSAIDs have different mechanisms of action, each with its own advantages and disadvantages. It is important to choose the appropriate treatment based on the symptoms and condition of the patient. Instead of self-judgment, it is recommended to consult a doctor or pharmacist and use them safely and effectively.

That’s all for today.