Japan’s New OTC PPI: Pariet S vs. Nexium and Prilosec
If you suffer from acid reflux or frequent heartburn and are traveling in Japan, you might be wondering what treatment options are available over the counter. While Nexium (esomeprazole) and Prilosec (omeprazole) are well-known OTC proton pump inhibitors (PPIs) overseas, Japan has just introduced a new PPI medication to the market: Pariet S, containing rabeprazole. As of June 2, 2025, Pariet S became available as an OTC treatment—but it comes with a catch: you need to consult a pharmacist in person to purchase it. In this article, we’ll introduce Pariet S and explain how it compares to international PPI options. What Is Pariet S? Pariet S is Japan’s first over-the-counter […]